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Glutamate indicators with increased sensitivity and tailored deactivation rates (iGluSnFR4), Code and Data Supplement

dataset
posted on 2025-10-01, 13:57 authored by Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring Iyer, Daniel ReepDaniel Reep, Anyi LiuAnyi Liu, Anirudh Palutla, Michael E. Xie, Bryan MacLennan, Kenta Hagihara, Lucas Kinsey, Julianna Sun, Pantong Yao, Jihong ZhengJihong Zheng, Arthur Tsang, Getahun Tsegaye, Yonghai Zhang, Ronak Patel, Ben ArthurBen Arthur, Julien Hiblot, Philipp Leippe, Miroslaw Tarnawski, Jonathan MarvinJonathan Marvin, Jason D. Vevea, Srinivas TuragaSrinivas Turaga, Alison G. Tebo, Matteo CarandiniMatteo Carandini, Federico Rossi, David KleinfeldDavid Kleinfeld, Arthur Konnerth, Karel Svoboda, Glenn TurnerGlenn Turner, Jeremy HassemanJeremy Hasseman, Kaspar PodgorskiKaspar Podgorski
<p dir="ltr">Development and characterization of iGluSnFR4, fourth generation fast (iGluSnFR4f) and slow (iGluSnFR4s) indicators for synaptic glutamate transmission.</p>

Funding

Measuring input-output operations of cortical neurons with large-scale neurotransmitter imaging

National Institute of Neurological Disorders and Stroke

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Optimization of genetically encoded voltage and neurotransmitter indicators for multiwavelength in vivo analysis of brain circuits

National Institute of Mental Health

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STUDYING SINGLE NEURON COMPUTATIONS WITHIN BRAIN-WIDE CIRCUITS

National Institute of Mental Health

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Paul and Daisy Soros Fellowship

Human Frontier Science Program LT0052/2022-L

Deutsche Forschungsgemeinschaft KO 979/7-1

Armenise-Harvard Foundation CDA

Human Technopole HT–ECF 3588

Boehringer Ingelheim Foundation

Biotechnology and Biological Sciences Research Council

Coding and wiring in a million cortical neurons

UK Research and Innovation

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American Lebanese Syrian Associated Charities

High- and low-level computations for coordination of orofacial motor actions

National Institute of Neurological Disorders and Stroke

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Direct wavefront sensing and adaptive optics to enable two-photon imaging axons and spines throughout all of cortex

National Institute of Biomedical Imaging and Bioengineering

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NIH R01NS143141

Optimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures

National Institute of Neurological Disorders and Stroke

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Schmidt Science Fellowship

Howard Hughes Medical Institute

Allen Institute for Neural Dynamics

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