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Resource Collection for a Connectome and Analysis of the Adult Drosophila Central Brain
online resourceposted on 18.08.2020, 14:37 by Louis SchefferLouis Scheffer, C. Shan Xu, Michal Januszewski, Zhiyuan LuoZhiyuan Luo, Shin-ya Takemura, Kenneth Hayworth, Gary HuangGary Huang, Kazunori Shinomiya, Jeremy Maitin-Shepard, Stuart Berg, Jody Clements, Philip HubbardPhilip Hubbard, William Katz, Lowell Umayam, Tingting Zhao, David AckermanDavid Ackerman, John BogovicJohn Bogovic, Tom Dolafi, Dagmar Kainmueller, Takashi Kawase, Khaled Khairy, Nicole Neubarth, Donald J. Olbris, Hideo Otsuna, Eric T. Trautman, Masayoshi Ito, Jens Goldammer, Tanya Wolff, Robert Svirskas, Philipp Schlegel, Erika R. Neace, Christopher J. Knecht Jr., Chelsea X. Alvarado, Dennis Bailey, Samantha Ballinger, Jolanta A. Borycz, Brandon Canino, Octave Duclos, Bryon Eubanks, Samantha Finley, Nora Forknall, Audrey Francis, Gary Patrick Hopkins, Emily E. Joyce, Sungjin Kim, Nicole A. Kirk, Julie Kovalyak, Shirley A. Lauchie, Alanna Lohff, Charli Maldonado, Emily A. Manley, Sari McLin, Caroline Mooney, Miatta Ndama, Omotara Ogundeyi, Nneoma Okeoma, Christopher Ordish, Nicholas Padilla, Christopher Patrick, Elliott E. Phillips, Emily M. Phillips, Neha Rampally, Caitlin Ribeiro, Madelaine K. Robertson, Jon Thomson Rymer, Sean M. Ryan, Megan Sammons, Anne K. Scott, Ashley L. Scott, Aya Shinomiya, Claire Smith, Kelsey A. Smith, Michael Cook, Larry Lindsey, Natalie L. Smith, Satoko Takemura, Tansy Yang, Jackie Swift, Marisa Dreher, Iris Talebi, Kelli Fairbanks, Margaret A. Sobeski, Natasha Cheatham, Alia Suleiman, Dorota Tarnogorska, Feng LiFeng Li, Emily Tenshaw, Temour Tokhi, John J. Walsh, Jane Anne Horne, Ruchi Parekh, Patricia K. Rivlin, Vivek JayaramanVivek Jayaraman, Kei Ito, Stephan Saalfeld, Reed George, Ian Meinertzhagen, Gerald M. Rubin, Harald Hess, Viren Jain, Alexander Bates, Gregory S.X.E. JefferisGregory S.X.E. Jefferis, Marta CostaMarta Costa, Stephen PlazaStephen Plaza
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.